RecombinantAscaris16‐Kilodalton Protein–Induced Protection againstAscaris suumLarval Migration after Intranasal Vaccination in Pigs

Pigs by Intranasal Vaccination with Live Strain ts-S34

Bordetella bronchiseptica is known to cause infectious atrophic rhinitis of swine (13) and rabbits (9), to cause respiratory diseases in dogs (1), and to bring about death due to sepsis of aninals such as mice (5), guinea pigs (5), and swine (M. Maeda and T. Shimizu, 83rd Meet. Jpn. Soc. Vet. Sci., Abstr. No. 66). Hitherto, killed vaccines were mainly studied for prophylaxis of B. bronchiseptic...

Respiratory PCR detects influenza after intranasal live-attenuated influenza vaccination

From 2013 an annual nasal live-attenuated influenza vaccine (LAIV—Fluenz) is available for all children in the UK aged 2 and 3 years and other ‘at-risk’ children, as part of the National Health Service (NHS) childhood vaccination programme. 2 The vaccine contains reassortant influenza viruses; two influenza A viruses (H1N1 and H3N2) and one influenza B virus, and has previously been used in chi...

Prophylaxis of Bordetella bronchiseptica infection in guinea pigs by intranasal vaccination with live strain ts-S34.

The temperature-sensitive mutant strain, ts-S34, of Bordetella bronchiseptica, which cannot grow at or above the temperature 34 degrees C, has been studied in guinea pigs. The strain grew to moderate numbers in the nasal turbinates but did not grow in the lungs. Guinea pigs given strain ts-S34 developed moderate levels of serum antibody. This strain also induced very high resistance to subseque...

Complex correlates of protection after vaccination.

In several prior articles I have attempted to analyze and simplify the subject of immunological functions induced by vaccination that correlate with protection against later exposure to pathogens. Other authors have also written on the subject, and recently we jointly proposed terminology to bring some semantic clarity to the field. The generalization that vaccine-induced antibodies prevent acq...

Intranasal Vaccination with Proinsulin DNA